Formulation: A solid
Formal Name: (αS)-N-[4-(aminocarbonyl)-3-fluorophenyl]-4-[5-chloro-2-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl]-α-ethyl-5-methoxy-2-oxo-1(2H)-pyridineacetamide
Purity: ≥98%
Formula Markup: C26H21ClF4N6O4
Formula Weight: 592,9
Shelf life (days): 1460
CAS Number: 2064121-65-7
Notes: BAY-2433334 is an inhibitor of Factor XIa (IC50 = 0.92 nM).{68924} It is greater than 1,000-fold selective for Factor Xa over FVIIa, FIXa, FXa, thrombin, urokinase, tissue plasminogen activator, and plasmin. BAY-2433334 increases clotting time in isolated human plasma (EC150 = 0.2 µM). In vivo, BAY-2433334 (10 and 30 mg/kg) reduces thrombus weight in a rabbit model of thrombosis induced by ferric chloride injury of the carotid artery.