BD 750, CAS 892686-59-8

Formulation: A solid

Formal Name: 2-(2-benzothiazolyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol

Purity: ≥98%

Formula Markup: C14H13N3OS

Formula Weight: 271,3

Shelf life (days): 1460

CAS Number: 892686-59-8

Notes: BD 750 is an immunosuppressant.{65870} It inhibits the proliferation of primary human and mouse T cells (IC50s = 1.1 and 1.5 µM, respectively) without inducing cytotoxicity when used at concentrations ranging from 3.13 to 50 µM. BD 750 induces cell cycle arrest at the G0/G1 phases in CD3 and CD28 antibody-activated primary human T cells when used at concentrations of 0.625, 2.5, and 10 µM and decreases the levels of cyclin D3 and cyclin-dependent kinase 6 (Cdk6) in CD3 and CD28 antibody-activated primary mouse T cells at 2.5 and 10 µM. It reduces the proliferation of IL-2-stimulated CTLL mouse T cells (IC50 = 1.2 µM) and decreases phosphorylated Stat5 levels in the same cells when used at concentrations of 5 and 20 µM. In vivo, BD 750 inhibits increases in ear thickness and ear patch weight in a mouse model of delayed-type hypersensitivity induced by 2,4-dinitrofluorobenzene.

• Artikelnummer: CAY37574-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37574-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK