Benproperine (phosphate), CAS 19428-14-9

Formulation: A solid

Formal Name: 1-[1-methyl-2-[2-(phenylmethyl)phenoxy]ethyl]-piperidine, monophosphate

Purity: ≥98%

Formula Markup: C21H27NO • H3PO4

Formula Weight: 407,4

Shelf life (days): 1460

CAS Number: 19428-14-9

Notes: Benproperine is an antitussive agent and actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor.{62747,62748} It increases the latency to first cough and decreases the number of coughs during and after a citric acid aerosol challenge in a guinea pig model of cough when administered at a dose of 27 mg/kg.{62747} It binds to ARPC2 and delays the initiation of actin polymerization in the presence of actin, the Arp2/3 complex, and the Wiskott-Aldrich syndrome protein (WASP) VCA domain, but not actin alone, when used at a concentration of 10 µM.{62748} Benproperine (1-10 µM) inhibits the migration and invasion of DLD-1 and AsPC-1 cancer cells and reduces lung metastasis in an AsPC-1 mouse model of metastasis when administered at a dose of 50 m/kg. Formulations containing benproperine have been used as cough suppressants.

• Artikelnummer: CAY35776-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35776-500
• Green Labware: Nein
• Verpackungseinheit: 500 mg
• Mengeneinheit: STK
• Methode: Reinstoffe