Betamethasone-d5, CAS 2244574-92-1

Formulation: A solid

Formal Name: 9-fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione-4,6,11,12,12-d5

Purity: ≥99% deuterated forms (d1-d5)

Formula Markup: C22H24D5FO5

Formula Weight: 397,5

Shelf life (days): 1460

CAS Number: 2244574-92-1

Notes: Betamethasone-d5 is intended for use as an internal standard for the quantification of betamethasone (Item No. 20363) by GC- or LC-MS. Betamethasone is a synthetic corticosteroid.{64715} In vivo, betamethasone (5 mg/kg) reduces bronchoalveolar lavage fluid (BALF) matrix metalloproteinase-2 (MMP-2) and MMP-9 activities, TNF-α levels, and neutrophil number in a mouse model of LPS-induced lung injury. Prenatal administration of betamethasone (0.1 mg/kg) improves neonatal lung function but decreases hippocampal and corpus callosum neuron density and induces motor function deficits in a rabbit model of late preterm birth.{64716} It also extends gestational length in a rat model of preterm labor induced by high mobility group protein B1 (HMGB1).{64717} Formulations containing betamethasone have been used in the treatment of inflammatory skin conditions and prenatally to promote fetal lung maturation.

• Artikelnummer: CAY39560-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39560-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung