BI-6015, CAS 93987-29-2

Formulation: A crystalline solid

Formal Name: 2-methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole

Purity: ≥95%

Formula Markup: C15H13N3O4S

Formula Weight: 331,3

Shelf life (days): 730

CAS Number: 93987-29-2

Notes: Hepatocyte nuclear factor 4α (HNF4α) is a nuclear receptor transcription factor that controls the expression of many genes including those involved in glucose and lipid homeostasis and maintenance of epithelial differentiation. BI-6015 is a small molecule antagonist of HNF4α that has been shown to repress the expression of known HNF4α target genes.{21357} At concentrations up to 20 μM, BI-6015 has been shown to reduce endogenous insulin gene expression by as much as 50-fold in T6PNE cells.{21357} The hepatocytes from livers of mice injected with 10 and 30 mg/kg BI-6015 exhibit marked, dose-dependent fat accumulation (steatosis).{21357} Additionally, at a daily dose of 30 mg/kg, BI-6015 induces apoptosis in a human hepatocellular carcinoma mouse model.{21357}

• Artikelnummer: CAY12032-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 12032-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK