BIBF 0775, CAS 334951-90-5

Formulation: A solid

Formal Name: (3Z)-N-ethyl-2,3-dihydro-N-methyl-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indole-6-carboxamide

Purity: ≥98%

Formula Markup: C31H34N4O2

Formula Weight: 494,6

Shelf life (days): 1460

CAS Number: 334951-90-5

Notes: BIBF 0775 is an inhibitor of TGF-β receptor type 1 (ALK5; IC50 = 34 nM).{65707} It is selective for ALK5 over VEGFR2 and PDGFRα (IC50s = 1,447 and 890 nM, respectively), as well as a panel of 30 other kinases at 1 µM.{65707,65708} BIBF 0775 inhibits the phosphorylation of SMAD2 and SMAD3 in HaCaT cells (EC50 = 105 nM) and is not cytotoxic to HaCaT cells (IC50 = >1,000 nM).{65707}

• Artikelnummer: CAY37777-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37777-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe