BLT2 Receptor Polyclonal Antibody

Formulation: 500 µl peptide affinity-purified polyclonal antibody

Immunogen: peptide from the C-terminal region of human BLT2

Shelf life (days): 1095

Notes: Leukotriene B4 (LTB4) promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, superoxide anion production, chemotaxis, and chemokinesis. Two G-protein coupled receptors, BLT1 and BLT2, which mediate the actions of LTB4 have been cloned and characterized.{8280,8743,8525,4425} The BLT1 receptor is expressed in leukocytes, U937 cells, and to a much lower extent in spleen and thymus.{4425} The human BLT2 receptor is a 358 amino acid protein with approximately 40% homology to BLT1 at the amino acid level.{8280,8743,8525} The BLT2 receptor is more broadly expressed than the BLT1 receptor, with highest levels observed in liver, spleen, ovary, intestine, and peripheral blood leukocytes.{8280,8743,8525} Activation of the BLT2 receptor by LTB4 leads to Ca2+ mobilization as well as decreases in cyclic AMP, indicating interaction of the receptor with Gq and Gi classes of G-proteins.{8743}

• Artikelnummer: CAY120124-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 120124-500
• Green Labware: Nein
• Verpackungseinheit: 1 ea (500 µl)
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Western Blotting
• Wirt: Rabbit