BMS 1166, CAS 1818314-88-3

Formulation: A crystalline solid

Formal Name: (4R)-1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxy-D-proline

Purity: ≥98%

Formula Markup: C36H33ClN2O7

Formula Weight: 641,1

Shelf life (days): 1460

CAS Number: 1818314-88-3

Notes: BMS 1166 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 1.4 nM in a homologous time-resolved fluorescence (HTRF) assay.{40457} It increases the activation of Jurkat cells expressing PD-1 in co-culture with CHO cells expressing PD-L1 (EC50 = 276 nM in a reporter assay).{59193}

• Artikelnummer: CAY31441-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31441-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK