BMS 470539 (hydrochloride), CAS 2341796-82-3

Formulation: A crystalline solid

Formal Name: 1-[1-(3-methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanone, dihydrochloride

Purity: ≥98%

Formula Markup: C32H41N5O4 • 2HCl

Formula Weight: 632,6

Shelf life (days): 730

CAS Number: 2341796-82-3

Notes: BMS 470539 is an agonist of melanocortin receptor 1 (MC1R).{38259} It induces cAMP accumulation in B16/F10 murine melanoma cells and in CHO cells overexpressing human MC1R (EC50s = 11.6 and 16.8 nM, respectively). It inhibits TNF-α-induced NF-κB activation in vitro in a concentration-dependent manner. In vivo, BMS 470539 inhibits LPS-induced TNF-α production in mice (ED50 = 10 μmol/kg, s.c.). It reduces LPS-induced leukocyte infiltration and paw swelling in mouse models of lung inflammation and delayed-type hypersensitivity, respectively. BMS 470539 decreases retinal damage in a mouse model of streptozotocin-induced diabetic retinopathy.{38260} It also increases striatal dopamine levels and decreases the number of striatal α-synuclein aggregates in a mouse model of Parkinson’s disease when administered at a dose of 20 mg/kg.{62919}

• Artikelnummer: CAY22231-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22231-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe