Brincidofovir, CAS 444805-28-1

Formulation: A solid

Formal Name: P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-phosphonic acid, mono[3-(hexadecyloxy)propyl] ester

Purity: ≥98%

Formula Markup: C27H52N3O7P

Formula Weight: 561,7

Shelf life (days): 1460

CAS Number: 444805-28-1

Notes: Brincidofovir is a prodrug form of the antiviral and acyclic nucleoside phosphonate cidofovir (Item No. 13113).{61832} Brincidofovir is converted to cidofovir in MRC-5 human lung fibroblasts. It inhibits CMV, herpes simplex virus 1 (HSV-1), HSV-2, cowpox, and vaccinia virus replication in plaque reduction assays (EC50s = 0.0009, 0.06, 0.08, 0.6, and ~1 µM, respectively). Brincidofovir decreases mortality in mouse models of cowpox or vaccinia virus infections when administered at doses of 6.7 or 5 mg/kg, respectively.{61833} Formulations containing brincidofovir have been used in the treatment of smallpox disease.

• Artikelnummer: CAY35062-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35062-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK