Bruceantin, CAS 41451-75-6

Formulation: A solid

Formal Name: (11β,12α,15β)-15-[[(2E)-3,4-dimethyl-1-oxo-2-penten-1-yl]oxy]-13,20-epoxy-3,11,12-trihydroxy-2,16-dioxo-picras-3-en-21-oic acid, methyl ester

Purity: ≥95%

Formula Markup: C28H36O11

Formula Weight: 548,6

Shelf life (days): 1460

CAS Number: 41451-75-6

Notes: Bruceantin is a quassinoid originally isolated from B. antidysenterica that has diverse biological activities.{54980,42191,54981} It inhibits protein synthesis in HeLa cells, reticulocytes, and reticulocyte lysates (IC50s = 30, 40, and 1,600 nM, respectively).{54980} Bruceantin is active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50s = 8 and 13 nM, respectively).{42191} It induces apoptosis in HL-60 leukemia and RPMI-8226 multiple myeloma cells (IC50s = 12.2 and 12.8 nM, respectively).{54981} Bruceantin (5 mg/kg) induces tumor regression in an RPMI-8226 mouse xenograft model.

• Artikelnummer: CAY33973-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33973-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe