c-CBL TR-FRET Assay Kit

Products from BPS Bioscience require a minimum order value above 400€

Applications: Great for screening small molecular inhibitors for drug discovery and HTS applications.

Description: Casitas B lineage lymphoma (c-Cbl) is a multifunctional protein with ubiquitin E3 ligase activity capable of degrading diverse sets of proteins. c-Cbl is a ubiquitously expressed mammalian protein that plays a vital role in fundamental cellular functions including cell survival, migration, and proliferation. Recent evidence suggests a critical role for c-Cbl in angiogenesis and human solid organ tumors, making it a potential drug target in cancer immunotherapy. The c-CBL TR-FRET Assay Kit is designed to measure c-CBL auto-ubiquitination activity in a homogeneous 384 reaction format. It utilizes Biotin-labeled Ubiquitin and a terbium-labeled anti-c-CBL antibody to complete the TR-FRET pairing. This FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications.

Storage Stability: At least 6 months from date of receipt when stored as directed.

Biosafety Level: Not applicable (BSL-1)

References: 1. Lyle, C.L., et al., Cell. 2019; 8(5): E498.

• Artikelnummer: BPS79786
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 79786
• Green Labware: Nein
• Verpackungseinheit: 384 rxns.
• Mengeneinheit: PAK