CA77.1, CAS 2412270-22-3

Formulation: A solid

Formal Name: N-[4-(6-chloro-2-quinoxalinyl)phenyl]-acetamide

Purity: ≥98%

Formula Markup: C16H12ClN3O

Formula Weight: 297,7

Shelf life (days): 1460

CAS Number: 2412270-22-3

Notes: CA77.1 is an inducer of chaperone-mediated autophagy (CMA).{62986} It induces the formation of autophagic lysosomes in NIH3T3 cells expressing a CMA reporter when used at concentrations of 10, 20, and 30 µM. CA77.1 (20 µM) induces autophagic flux in NIH3T3 cells. In vivo, CA77.1 (30 mg/kg) reduces locomotor hyperactivity to control levels and the number of neurons containing pathogenic tau conformations in the hippocampus, amygdala, and piriform cortex in a PS19 transgenic mouse model of Alzheimer's disease.

• Artikelnummer: CAY37300-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37300-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Reinstoffe