Camptothecin, CAS 7689-03-4

Topoisomerase I inhibitor

Product Type: Inhibitor

CAS No.: 7689-03-4

MolecularFormula: C20H16N2O4

Molecular Weight: 348,36

Source: Synthetic

Purity: >98%

Solubility: Soluble to 5 mM in DMSO

Appearance: Yellow solid

PubChem CID: 24360

Scientific Background: Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I. It binds to the topo I and DNA complex, resulting in a tertiary comlex which stabilizes it. This prevents re-ligation and therefore causes DNA damage which results in apoptosis (1-3). It has showed remarkable anti-cancer activity in clinical trials.

References: 1. Adams D.J., et al. (2005) Cancer Chem and Pharm. 57(2): 145-154.2. Redinbo M.R., Stewart L., Kuhn P., Champoux J.J. and Hol W.G.J. (1998) Science. 279:1504-1513.3. Pommier Y., et al. (2003) Mutat Res. 532: 173-203.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-242-1G
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-242-1G
• Verpackungseinheit: 1 g
• Mengeneinheit: STK