Product Type: Activator
CAS No.: 3650-09-7
MolecularFormula: C20H28O4
Molecular Weight: 332,43
Source: Synthetic
Purity: ≥95% (HPLC); NMR(Conforms)
Solubility: Soluble in DMSO (50 mg/ml)
Appearance: Off white to yellow solid
PubChem CID: 65126
Scientific Background: Carnosic acid is a benzenediol abietane diterpene naturally extracted from rosemary (Rosmarinus officinalis) and sage (Saliva officinalis). It is a potent antioxidant that inhibits NADH or NADPH induced lipid peroxidation by acting as a free radical scavenger (1). It has been found to increase cellular levels of glutathione (GSH) and prevent 6-hydroxydopamine-induced cell death in SH-SY5Y cells (2). Carnosic acid-stimulation of GSH also inhibits adipocyte differentiation (3). It has also been found to induce apoptosis (4) and inhibit the proliferation and migration of various tumor cell lines (5).
References: 1. Schwarz K., Ternes W. (1992) Zeitschrift für Lebensmittel-Untersuchung und –Forschung. 195 (2): 99-103.2. Chen J.H., et al. Chem. (2012) Res. Toxicol 25:1893.3. Takahashi T., et al. (2009) Biochem. Biophys. Res. Commun. 382:549.4. Kar S., et al. (2012) Apoptosis. 17:1735.5. Barni M.V., et al. (2012) Oncol. Rep. 27:1041.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.