Cav1.2 Antibody, Clone S57: HRP

Mouse Anti-Rabbit Cav1.2 Monoclonal IgG1

Target: Cav1.2

Conjugate: HRP

Product Type: Monoclonal

Clone Number: S57

Immunogen: Fusion protein amino acids 1507-1733 (intracellular carboxyl terminus) of rabbit Cav1.2

Swiss-Prot: P15381

Purification: Protein G Purified

Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Detects ~240kDa (varies with cell background due to glycosylation).

Cellular Localization: Membrane,Cell Membrane

Scientific Background: Cav1.2 is a cardiac L-type calcium channel, and is important for excitation and contraction of the heart (1). It may be associated with a variant of Long QT syndrome called Timothy's syndrome (2, 3) and also with Brugada syndrome. Some references also suggest it is related to bipolar disease as well (3).

References: 1. Splawski I., et al. (2004) Cell. 119 (1): 19-31.2. Krey J.F., and Dolmetsch R. (2009) Biophysical. 96 (3): 221a-222a.3. Crotti L., Celano G., Dagradi F. and Schwartz P.J. (2008) Orphanet J Rare Disease 3:18.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-300D-HRP
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-300D-HRP
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus), Hamster
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunoprecipitation, Western Blotting, Immunohistochemistry, Immunocytochemistry
• Isotyp: IgG1
• Human Gene ID: 100101555
• Wirt: Mouse