CCR2 Antagonist, CAS 445479-97-0

Formulation: A solid

Formal Name: rel-2-[[[(1-methylethyl)amino]carbonyl]amino]-N-[2-[[(1R,2S)-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)-benzamide

Purity: ≥98%

Formula Markup: C28H34F3N5O4S

Formula Weight: 593,7

Shelf life (days): 1460

CAS Number: 445479-97-0

Notes: CCR2 antagonist is an antagonist of chemokine (C-C motif) receptor 2 (CCR2).{49940} It binds to CCR2 in a radioligand binding assay using peripheral blood mononuclear cells (PBMCs; IC50 = 5.1 nM). CCR2 antagonist inhibits chemotaxis induced by chemokine (C-C motif) ligand 2 (CCL2) in PBMCs (IC50 = 1 nM). In vivo, CCR2 antagonist (2 mg/kg) reduces hepatic Ly6C+ monocyte recruitment and viral clearance in mice infected with hepatitis B virus (HBV).{49941}

• Artikelnummer: CAY19542-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 19542-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK