Product Type: Inhibitor
CAS No.: 1163719-56-9
MolecularFormula: C27H24FN7O3
Molecular Weight: 513,53
Source: Synthetic
Purity: 96%
Solubility: Soluble in DMSO
Appearance: White Solid
Scientific Background: CCT196969, a pan-RAF/SFK inhibitor is active against treatment-naive BRAF and NRAS mutant melanoma tumors. It is also active in tumors from patients who developed resistance to BRAF-selective inhibitors and a BRAF plus MEK inhibitor combination. IC50 0.1µM and 0.03µM for BRAF kinase and SRC kinase respectively.
References: 1. Girotti, M.R., et al. (2015) Cancer Cell 27.1: 85-96.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.