CD137 (4-1BB) /NF-κB Reporter - HEK293 Recombinant Cell Line

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Applications: Screen for activators or inhibitors of CD137 signaling in a cellular context Characterize the biological activity of CD137 and its interactions with ligands

Background: Human CD137 (4-1BB; TNFRS9) is an inducible co-stimulatory molecule that activates T cells. CD137:CD137L-mediated signaling has been shown to be important for proliferation, effector functions and survivals of T cells. CD137 is also expressed in NK and NKT cells. Accumulating evidence shows a role for CD137:CD137L signaling in inflammation, suggesting that inhibition of this pathway may provide a therapeutic avenue to treat autoimmune and inflammatory diseases. Similarly, antibodies targeting CD137 activation in immune cells have demonstrated potent anti-tumor properties in cancer patients.

Description: Recombinant HEK293 cell line expressing a full length human CD137 (NM_003811). The NF-κB luciferase reporter construct is stably integrated into the genome. The firefly luciferase gene is controlled by 4 copies of NF-κB response element located upstream of the TATA promoter. Following activation by human CD137 ligand, NF-κB transcription factors bind to the DNA response elements to induce transcription of the luciferase gene.

Format: Each vial contains 2 x 10^6 cells in 1 ml of 10% DMSO in FBS.

Host Cell Line: HEK293

Storage Stability: Store in liquid nitrogen immediately upon receipt.

Biosafety Level: BSL-2

• Artikelnummer: BPS79289
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 79289
• Verpackungseinheit: 2 vials
• Mengeneinheit: PAK
• Wirt: Human