CD3 antibody (17A2) (APC)

Clone Name: 17A2

Light Chain: Kappa

Product Description: The 17A2 antibody reacts with the mouse CD3 complex, comprised of CD3 epsilon, CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells. The 17A2 antibody is a widely used phenotypic marker for mouse T cells. In addition, as the CD3e chain within the TCR complex contains intracellular signaling domains, binding of 17A2 antibody to CD3 can induce cell activation (use format suitable for functional assays).

Application Note: *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Form: Liquid

Buffer (with preservative): 10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin, 0.09% Sodium azide.

Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Uniprot ID: P22646/P04235/P11942/P24161

Purification: Purified by affinity chromatography

Conjugation: APC

Full Name: CD3 antigen, delta polypeptide/CD3 antigen, epsilon polypeptide/CD3 antigen, gamma polypeptide/CD247 antigen

• Artikelnummer: GTX01458-07-100
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX01458-07-100
• Green Labware: Nein
• Verpackungseinheit: 100 μg
• Mengeneinheit: STK
• Reaktivität: Mouse (Murine)
• Klonalität: Monoclonal
• Methode: Flow Cytometry
• Isotyp: IgG2b
• Human Gene ID: 12502
• Wirt: Rat