CD38 Inhibitor Screening Assay Kit (Cyclase Activity)

Products from BPS Bioscience require a minimum order value above 400€

Applications: Great for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.

Background: CD38, a differentiation antigen of B lymphocytes, is a type II integral membrane protein. It is also known as ADP-ribosyl cyclase and nicotinamide adenine dinucleotide (NAD+) glycohydrolase. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in various cells, including pancreatic B cells. CD38 is a prognostic biomarker for acute B lymphoblastic leukemia.

Description: The CD38 Inhibitor Screening Assay Kit (Cyclase Activity) is designed to measure the cyclase activity of CD38 for screening and profiling applications. The CD38 assay kit comes in a convenient 96-well format, with purified recombinant CD38 enzyme, its substrate nicotinamide guanine dinucleotide (NGD+), and CD38 assay buffer for 100 enzyme reactions. In addition, the kit includes the CD38 inhibitor quercitin for use as an inhibitor control.

Storage Stability: Up to 6 months from date of receipt, when stored as recommended.

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: Wei, W., et al., World J. Biol. Chem. 2014 5(1):58-67.

• Artikelnummer: BPS71275
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 71275
• Green Labware: Nein
• Verpackungseinheit: 96 rxns.
• Mengeneinheit: PAK