CD38 (Mouse) Fluorogenic Assay Kit (Cyclase Activity)

Products from BPS Bioscience require a minimum order value above 400€

Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.

Background: CD38, a differentiation antigen of B lymphocytes, is a type II integral membrane protein. It is also known as ADP-ribosyl cyclase and nicotinamide adenine dinucleotide (NAD+) glycohydrolase. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in various cells, including pancreatic b cells, where it regulates insulin secretion. CD38 is a prognostic biomarker for acute B lymphoblastic leukemia, and anti-CD38 antibodies are in clinical trials as therapeutics for multiple myeloma.

Description: The CD38 (Mouse) Inhibitor Screening Assay Kit (Cyclase Activity) is designed to measure the cyclase activity of CD38 (mouse) for screening and profiling applications. The CD38 assay kit comes in a convenient 96-well format, with purified recombinant CD38 enzyme, its substrate nicotinamide guanine dinucleotide (NGD+), and CD38 assay buffer for 100 enzyme reactions. In addition, the kit includes the CD38 inhibitor quercetin for use as an inhibitor control.

Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.

Supplied As: The CD38 assay kit comes in a convenient 96-well format, with purified recombinant CD38 enzyme, its substrate nicotinamide guanine dinucleotide (NGD+), and CD38 assay buffer for 100 enzyme reactions.

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: Wei, W., et al., World J. Biol. Chem. 2014, 5(1):58-67.

• Artikelnummer: BPS78285
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 78285
• Green Labware: Nein
• Verpackungseinheit: 96 rxns.
• Mengeneinheit: PAK