CD4, Avi-Tag, His-Tag, HiP™ Recombinant

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Encompassing Amino Acids: 26-396

Background: CD4 (cluster of differentiation 4) is part of the immunoglobulin superfamily, and is found in T-helper cells, monocytes, macrophages and dendritic cells. It is a co-receptor in the TCR (T-cell receptor), binding to MHC (major histocompatibility complex) class II molecules. CD4 binds to the tyrosine kinase Lck (lymphocyte-specific protein tyrosine kinase), which can phosphorylate the ITAM (immunoreceptor tyrosine activation motifs) domain of the CD3, activating CD3-related signaling. CD4 is a typical marker of T helper cells, and it has been linked to cancer, autoimmune diseases such as vitiligo and type I diabetes. In addition, HIV-1 uses CD4 as a cellular receptor to trigger viral envelope protein conformational changes that allow cell infection. Further studies into CD4 and potential strategies around it may benefit patients and CD4 related diseases.

Description: Human recombinant CD4, encompassing amino acids 26-396 which correspond to the extracellular domain. This construct contains a C-terminal Avi-Tag™ followed by an His-Tag (6xHis). This protein was affinity purified. HiP™ indicates a high purity protein (≥90% pure) and less than 10% aggregation as measured by gel filtration.

Format: Aqueous buffer solution.

Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol

Genbank: NM_000616.5

Host Cell Line: HEK293

Purity: ≥90%

Storage Stability: At least 6 months at -80°C.

Tags: C-terminal Avi-Tag™, His-Tag

Uniprot: P01730

Warnings: Avoid freeze/thaw cycles

Biosafety Level: Not applicable (BSL-1)

• Artikelnummer: BPS101862
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 101862
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Wirt: Human