CD40L / CD154 antibody (5C8) (PE)

Clone Name: 5C8

Light Chain: Kappa

Product Description: The 5C8 antibody reacts with human CD154 which is also known as CD40L (CD40 ligand). CD154 is a 39kDa member of the TNF-α superfamily and is predominantly expressed on activated T cells but is also expressed on NK cells, mast cells, basophils, and eosinophils. CD154 binds to CD40, a molecule that is expressed on antigen presenting cells including B cells, monocytes/macrophages, and dendritic cells. The interaction of CD154 and CD40 regulates the activation of antigen presenting cells and is critical for B cell costimulation. The 5C8 antibody has been reported to block CD40L-CD40 interactions.

Application Note: FACS: 0.25 μg (5 μl) for 10⁵-10⁸ cells in 100 μl sample per test. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 29

Form: Liquid

Buffer (with preservative): 10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin, 0.09% Sodium azide.

Concentration: 0.05 mg/ml (Please refer to the vial label for the specific concentration.)

Background: The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]

Uniprot ID: P29965

Purification: Purified by affinity chromatography

Conjugation: PE

Full Name: CD40 ligand

• Artikelnummer: GTX01484-08-100
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX01484-08-100
• Green Labware: Nein
• Verpackungseinheit: 100 test
• Mengeneinheit: PAK
• Reaktivität: Human, Cynomolgus Monkey (Primate), Rhesus Monkey (Primate)
• Klonalität: Monoclonal
• Methode: Flow Cytometry
• Isotyp: IgG2a
• Human Gene ID: 959
• Wirt: Mouse