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CD8a/CD8b Jurkat Cell Line
CD8a/CD8b Jurkat Cell Line
Artikelnummer
BPS78917
Verpackungseinheit
2 vials
Hersteller
BPS Bioscience
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Products from BPS Bioscience require a minimum order value above 400€
Applications: Study CD8/MHCI complex formation and inhibition.
Background: CD8 (cluster of differentiation 8) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that functions within the immune system to mediate cell-cell interactions. CD8 is a co-receptor for the TCR (T cell receptor) in T cells, binding to MHC (major histocompatibility complex) class I proteins. CD8 is a typical marker of cytotoxic T cells and is involved in signaling. CD8 has two isoforms, a and b. CD8b recruits Lck (lymphocyte-specific protein tyrosine kinase) to the TCR-CD3 complex, and Lck phosphorylates multiple proteins involved in activation of cytotoxic T lymphocytes. It is thus critical for the lysis of cancer cells. Studying CD8 and its importance in iso-immunity can further our understanding of post-transplant recognition and its potential for cancer therapy.
Description: The CD8a/CD8b Jurkat Cell Line are human T lymphocyte Jurkat cells (Clone# E6-1) engineered to express CD8a (NM_ 001768.6) and CD8b (NM_004931.5) driven by an EF1a promoter. The cells were generated by transduction with CD8a/CD8b Lentivirus (BPS Bioscience #78650), which is a SIN (self-inactivating) lentivirus. The cells also express very low levels of endogenous CD4.
Host Cell Line: Jurkat (clone# E6-1), human T lymphocyte cell line, suspension.
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage. Contact technical support at support@bpsbioscience.com if the cells are not frozen in dry ice upon arrival.
Supplied As: Each vial contains ~1 x 106 cells in 1 ml of Cell Freezing Medium (BPS Bioscience #79796)
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-1
Applications: Study CD8/MHCI complex formation and inhibition.
Background: CD8 (cluster of differentiation 8) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that functions within the immune system to mediate cell-cell interactions. CD8 is a co-receptor for the TCR (T cell receptor) in T cells, binding to MHC (major histocompatibility complex) class I proteins. CD8 is a typical marker of cytotoxic T cells and is involved in signaling. CD8 has two isoforms, a and b. CD8b recruits Lck (lymphocyte-specific protein tyrosine kinase) to the TCR-CD3 complex, and Lck phosphorylates multiple proteins involved in activation of cytotoxic T lymphocytes. It is thus critical for the lysis of cancer cells. Studying CD8 and its importance in iso-immunity can further our understanding of post-transplant recognition and its potential for cancer therapy.
Description: The CD8a/CD8b Jurkat Cell Line are human T lymphocyte Jurkat cells (Clone# E6-1) engineered to express CD8a (NM_ 001768.6) and CD8b (NM_004931.5) driven by an EF1a promoter. The cells were generated by transduction with CD8a/CD8b Lentivirus (BPS Bioscience #78650), which is a SIN (self-inactivating) lentivirus. The cells also express very low levels of endogenous CD4.
Host Cell Line: Jurkat (clone# E6-1), human T lymphocyte cell line, suspension.
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage. Contact technical support at support@bpsbioscience.com if the cells are not frozen in dry ice upon arrival.
Supplied As: Each vial contains ~1 x 106 cells in 1 ml of Cell Freezing Medium (BPS Bioscience #79796)
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-1
| Artikelnummer | BPS78917 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 78917 |
| Verpackungseinheit | 2 vials |
| Mengeneinheit | PAK |
| Wirt | Human |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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Gernot Ensinger, M.Sc.
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