CDKI-73, CAS 1421693-22-2

Formulation: A solid

Formal Name: 3-[[5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-2-pyrimidinyl]amino]-benzenesulfonamide

Purity: ≥98%

Formula Markup: C15H15FN6O2S2

Formula Weight: 394,4

Shelf life (days): 1460

CAS Number: 1421693-22-2

Notes: CDKI-73 is an inhibitor of Cdk9/cyclin T1, Cdk1/cyclin B, and Cdk2/cyclin A complexes (Kis = 4, 4, and 3 nM, respectively).{67816} It is selective for these complexes over the Cdk7/cyclin H complex (Ki = 91 nM). CDKI-73 is cytotoxic to HCT116 colorectal cancer cells (GI50 = In vivo, CDKI-73 (100 mg/kg every three days) decreases tumor volume in an HCT116 mouse xenograft model to a greater extent than the DNA-crosslinking agent cisplatin (Item No. 13119).

• Artikelnummer: CAY41099-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 41099-50
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK