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CEACAM5 Lentivirus
CEACAM5 Lentivirus
Artikelnummer
BPS78719
Verpackungseinheit
500 µl x 2
Hersteller
BPS Bioscience
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Applications: Generate a stable cell line expressing human CEACAM5 with puromycin selection
Background: Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5, also known as CD66e) is a cell surface glycoprotein that serves as a cell adhesion protein. It has been used as a clinical biomarker to detect liver metastasis from gastrointestinal cancers and to predict gastrointestinal cancer relapse. CEACAM5 was recently identified as a potential target antigen for CAR T-cell therapy. Additionally, CEACAM5 may be involved in the inhibition of cell differentiation, apoptosis, and cell polarity.
Description: The CEACAM5 Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce nearly all types of mammalian cells, including primary and non-dividing cells. The particles contain a human CEACAM5 (NM_004363.6) driven by an EF1A promoter and a puromycin selection marker (Figure 1).
Figure 1: Schematic of the lenti-vector used to generate the CEACAM5 Lentivirus
Formulation: The lentivirus particles were produced from HEK293T cells. They are supplied in cell culture medium containing 90% DMEM + 10% FBS.
Storage Stability: Lentiviruses are shipped with dry ice. For long-term storage, it is recommended to store the lentiviruses at -80°C.
Supplied As: Two vials (500 µl x 2) of lentivirus at a titer ≥107 TU/ml. The titer will vary with each lot; the exact value is provided with each shipment.
Uniprot: P06731
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-2
Applications: Generate a stable cell line expressing human CEACAM5 with puromycin selection
Background: Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5, also known as CD66e) is a cell surface glycoprotein that serves as a cell adhesion protein. It has been used as a clinical biomarker to detect liver metastasis from gastrointestinal cancers and to predict gastrointestinal cancer relapse. CEACAM5 was recently identified as a potential target antigen for CAR T-cell therapy. Additionally, CEACAM5 may be involved in the inhibition of cell differentiation, apoptosis, and cell polarity.
Description: The CEACAM5 Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce nearly all types of mammalian cells, including primary and non-dividing cells. The particles contain a human CEACAM5 (NM_004363.6) driven by an EF1A promoter and a puromycin selection marker (Figure 1).
Figure 1: Schematic of the lenti-vector used to generate the CEACAM5 LentivirusFormulation: The lentivirus particles were produced from HEK293T cells. They are supplied in cell culture medium containing 90% DMEM + 10% FBS.
Storage Stability: Lentiviruses are shipped with dry ice. For long-term storage, it is recommended to store the lentiviruses at -80°C.
Supplied As: Two vials (500 µl x 2) of lentivirus at a titer ≥107 TU/ml. The titer will vary with each lot; the exact value is provided with each shipment.
Uniprot: P06731
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-2
| Artikelnummer | BPS78719 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 78719 |
| Green Labware | Nein |
| Verpackungseinheit | 500 µl x 2 |
| Mengeneinheit | STK |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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