Formulation: A crystalline solid
Formal Name: (4R)-2′-deoxy-2′,2′-difluoro-3,4,5,6-tetrahydro-uridine
Purity: ≥98%
Formula Markup: C9H14F2N2O5
Formula Weight: 268,2
Shelf life (days): 1460
CAS Number: 1141397-80-9
Notes: Cedazuridine is an inhibitor of cytidine deaminase (IC50 = 0.4 µM).{66444} It increases plasma levels of decitabine via inhibition of its metabolism by cytidine deaminase in rhesus monkeys when administered at doses of 1 and 10 mg/kg. Cedazuridine (3 mg/kg) induces decreases in leukemic cell expansion in combination with orally administered 5-azacytidine (Item No. 11164), which is inactive as a single agent, in the bone marrow and spleen in a MOLM-13 acute myeloid leukemia (AML) mouse xenograft model.{66445} Formulations containing cedazuridine in combination with decitabine have been used in the treatment of myelodysplastic syndrome (MDS).