Cig2(3A11/5), 0.2mg/mL

Description: Cig2 is a cyclin that functions as the catalytic subunit of cyclin-dependent kinases (Cdks) in the fission yeast Schizosaccharomyces pombe. It is a B-type, S phase cyclin that is required for both the G1/S and G2/M cell cycle transitions and is expressed in a sharp spike that peaks during the G1/S period. Cig2 binds to Cdc2 (Cdk), and the resulting Cdc2/Cig2 complex controls the G1/S transition of the cell cycle. Disruption of Cig2 delays the onset of mitosis. The expression of the Cig2 gene is dependent on Mlu1-binding factor (MBF), and the protein is destroyed during anaphase by the APC/cyclosome (APC/C) and Skp1/Cullin-1/F-box (SCF), thereby ensuring the spike expression pattern of Cig2. SCF regulates Cig2 levels in a dual manner, transcriptionally and post-translationally, while APC/C only destroys the protein. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Conjugate: Purified, with BSA

Concentration: 0.2 mg/mL

Storage buffer: PBS, 0.05% BSA, 0.05% azide

Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)

Clone: 3A11/5

Entrez Gene ID: Not Known

Immunogen: Bacterial S. pombe Cig2 Purified protein.

• Artikelnummer: BTMBNUB2827-500
• Hersteller: Biotium
• Hersteller Artikelnummer: BNUB2827-500
• Verpackungseinheit: 500 uL
• Mengeneinheit: STK
• Reaktivität: Various species
• Klonalität: Monoclonal
• Isotyp: IgG1 kappa
• Wirt: Mouse