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cKIT (D816V) Assay Kit
cKIT (D816V) Assay Kit
Artikelnummer
BPS79889
Verpackungseinheit
96 rxns.
Hersteller
BPS Bioscience
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Products from BPS Bioscience require a minimum order value above 400€
Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: c-KIT is a proto-oncogene and a type III transmembrane receptor for mast cell growth factor, also known as stem cell factor. It plays an essential role in the regulation of cell survival and proliferation, as well as hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and mast cell development, migration and function. The D816V substitution in the cKIT kinase domain has been identified in peripheral blood mononuclear cells of patients suffering from mastocytosis with an associated hematologic disorder. Gastrointestinal stromal tumors (GIST), acute myeloid leukemia, and germ cell tumors have also been demonstrated to carry this mutation.
Description: The cKIT (D816V) Assay Kit is designed to measure cKIT (D816V) activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
Storage Stability: Up to 6 months when stored as recommended.
Supplied As: The cKIT (D816V) Assay Kit comes in a convenient 96-well format, with enough purified recombinant cKIT (D816V) enzyme, Protein Tyrosine Kinase Substrate (Poly-Glu,Tyr 4:1), ATP, and kinase assay buffer for 100 enzyme reactions.
Warnings: Avoid multiple freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Schumaker, J.A., et al. (2008) J. Clin. Pathol. 61:109-114.
2. Sun, J. et al. (2009) J. Biol. Chem. 284: 11039-11047.
Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: c-KIT is a proto-oncogene and a type III transmembrane receptor for mast cell growth factor, also known as stem cell factor. It plays an essential role in the regulation of cell survival and proliferation, as well as hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and mast cell development, migration and function. The D816V substitution in the cKIT kinase domain has been identified in peripheral blood mononuclear cells of patients suffering from mastocytosis with an associated hematologic disorder. Gastrointestinal stromal tumors (GIST), acute myeloid leukemia, and germ cell tumors have also been demonstrated to carry this mutation.
Description: The cKIT (D816V) Assay Kit is designed to measure cKIT (D816V) activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
Storage Stability: Up to 6 months when stored as recommended.
Supplied As: The cKIT (D816V) Assay Kit comes in a convenient 96-well format, with enough purified recombinant cKIT (D816V) enzyme, Protein Tyrosine Kinase Substrate (Poly-Glu,Tyr 4:1), ATP, and kinase assay buffer for 100 enzyme reactions.
Warnings: Avoid multiple freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Schumaker, J.A., et al. (2008) J. Clin. Pathol. 61:109-114.
2. Sun, J. et al. (2009) J. Biol. Chem. 284: 11039-11047.
| Artikelnummer | BPS79889 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 79889 |
| Green Labware | Nein |
| Verpackungseinheit | 96 rxns. |
| Mengeneinheit | PAK |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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