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Claudin-18 Isoform 2 CHO Cell Line (High, Medium, or Low Expression)
Claudin-18 Isoform 2 CHO Cell Line (High, Medium, or Low Expression)
Artikelnummer
BPS78533
Verpackungseinheit
2 vials
Hersteller
BPS Bioscience
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Products from BPS Bioscience require a minimum order value above 400€
Applications: Test antibodies against claudin 18.2Screen inhibitors or neutralizing antibodies against claudin 18.2
Background: Claudins are integral membrane proteins and components of tight junction strands which serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. The claudin-18 gene has two splice variants: claudin-18.1, which is found primarily in the lung, and claudin-18.2, which is expressed exclusively in the stomach. Claudin-18.2 is highly expressed in gastric and pancreatic adenocarcinoma, located in the outer cell membrane, and involved in tumor development and progression. In addition, it has exposed extracellular loops and is available for monoclonal antibody binding. These biological characteristics suggest that it is an ideal target for therapy and have led to the further development of monoclonal antibodies against claudin 18.2, such as Zolbetuximab.
Description: Recombinant clonal CHO cell line stably expressing full length human claudin 18.2 (claudin18 isoform 2, CLDN18.2, gene accession number NM_001002026.3). The stable clonal cell line was selected for high levels of claudin 18.2 expression compared to the parental CHO-K1 cell line.
Host Cell Line: CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.
Supplied As: Each vial contains 2 x 106 cells in 1 ml of cell freezing medium (BPS Bioscience #79796)
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-1
Applications: Test antibodies against claudin 18.2Screen inhibitors or neutralizing antibodies against claudin 18.2
Background: Claudins are integral membrane proteins and components of tight junction strands which serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. The claudin-18 gene has two splice variants: claudin-18.1, which is found primarily in the lung, and claudin-18.2, which is expressed exclusively in the stomach. Claudin-18.2 is highly expressed in gastric and pancreatic adenocarcinoma, located in the outer cell membrane, and involved in tumor development and progression. In addition, it has exposed extracellular loops and is available for monoclonal antibody binding. These biological characteristics suggest that it is an ideal target for therapy and have led to the further development of monoclonal antibodies against claudin 18.2, such as Zolbetuximab.
Description: Recombinant clonal CHO cell line stably expressing full length human claudin 18.2 (claudin18 isoform 2, CLDN18.2, gene accession number NM_001002026.3). The stable clonal cell line was selected for high levels of claudin 18.2 expression compared to the parental CHO-K1 cell line.
Host Cell Line: CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.
Supplied As: Each vial contains 2 x 106 cells in 1 ml of cell freezing medium (BPS Bioscience #79796)
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-1
| Artikelnummer | BPS78533 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 78533 |
| Verpackungseinheit | 2 vials |
| Mengeneinheit | PAK |
| Wirt | Hamster |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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Gernot Ensinger, M.Sc.
Laurent Haze
