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Claudin-9 Lentivirus
Claudin-9 Lentivirus
Artikelnummer
BPS78721
Verpackungseinheit
500 µl x 2
Hersteller
BPS Bioscience
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Products from BPS Bioscience require a minimum order value above 400€
Applications: Generate stable cell line expressing human Claudin-9 with puromycin selection
Background: Claudins are integral membrane proteins and major components of tight junction strands which serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin-9 is one of the 27 members of the Claudin family.Claudin-9 is overexpressed in hepatocellular carcinoma, where it enhances the metastatic potential of hepatocytes via Tyk2/Stat3 signaling. Claudin-9 is also a marker for endometrial cancer, and acts as a receptor for Clostridium perfringens enterotoxin (CPE) during infection by gram-positive Clostridial bacteria. C. perfringens infection causes for food poisoning and gastrointestinal illnesses, via Claudin-9 to toxin-induced gut barrier breakdown.
Description: The Claudin-9 Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce nearly all types of mammalian cells, including primary and non-dividing cells. The particles contain a human Claudin-9 (NM_020982) driven by an EF1A promoter and a puromycin selection marker (Figure 1).
Figure 1: Schematic of the lenti-vector used to generate the Claudin-9 Lentivirus.
Formulation: The lentivirus particles were produced from HEK293T cells. They are supplied in cell culture medium containing 90% DMEM + 10% FBS.
Storage Stability: Lentiviruses are shipped with dry ice. For long-term storage, it is recommended to store the lentiviruses at -80°C.
Supplied As: Two vials (500 µl x 2) of lentivirus at a titer ≥107 TU/ml. The titer will vary with each lot; the exact value is provided with each shipment.
Uniprot: O95484
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-2
Applications: Generate stable cell line expressing human Claudin-9 with puromycin selection
Background: Claudins are integral membrane proteins and major components of tight junction strands which serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin-9 is one of the 27 members of the Claudin family.Claudin-9 is overexpressed in hepatocellular carcinoma, where it enhances the metastatic potential of hepatocytes via Tyk2/Stat3 signaling. Claudin-9 is also a marker for endometrial cancer, and acts as a receptor for Clostridium perfringens enterotoxin (CPE) during infection by gram-positive Clostridial bacteria. C. perfringens infection causes for food poisoning and gastrointestinal illnesses, via Claudin-9 to toxin-induced gut barrier breakdown.
Description: The Claudin-9 Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce nearly all types of mammalian cells, including primary and non-dividing cells. The particles contain a human Claudin-9 (NM_020982) driven by an EF1A promoter and a puromycin selection marker (Figure 1).
Figure 1: Schematic of the lenti-vector used to generate the Claudin-9 Lentivirus.Formulation: The lentivirus particles were produced from HEK293T cells. They are supplied in cell culture medium containing 90% DMEM + 10% FBS.
Storage Stability: Lentiviruses are shipped with dry ice. For long-term storage, it is recommended to store the lentiviruses at -80°C.
Supplied As: Two vials (500 µl x 2) of lentivirus at a titer ≥107 TU/ml. The titer will vary with each lot; the exact value is provided with each shipment.
Uniprot: O95484
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-2
| Artikelnummer | BPS78721 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 78721 |
| Green Labware | Nein |
| Verpackungseinheit | 500 µl x 2 |
| Mengeneinheit | STK |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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Gernot Ensinger, M.Sc.
Laurent Haze
