CNOT1 Polyclonal Antibody, Rabbit

Abbreviation: CNOT1

Target Synonym: CNOT1;AD-005;CDC39;NOT1;NOT1H

Conjugation: Unconjugated

UNIProt ID: A5YKK6

Background: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES cell identity.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human CNOT1

Dilution: WB 1:200-1:2000,IF 1:50-1:200

• Artikelnummer: ELSE-AB-92695-120
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-E-AB-92695-120
• Green Labware: Nein
• Verpackungseinheit: 120 µl
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine)
• Klonalität: Polyclonal
• Methode: Immunofluorescence, Western Blotting
• Isotyp: IgG
• Wirt: Rabbit