COX-1 Monoclonal Antibody (Clone CX111)

Formulation: 500 µg of purified monoclonal antibody

Immunogen: Purified ovine COX-1

Clone Designation: CX111

Shelf life (days): 1095

Notes: Cyclooxygenase 1 (COX-1) is a bifunctional enzyme that exhibits both COX and peroxidase activities.{500,501} It is composed of an N-terminal signal peptide, an EGF-like domain, a membrane binding domain, a catalytic domain, and a C-terminal tail.{4376} COX-1 is constitutively expressed in the gastrointestinal tract, kidney, spleen, liver, and lung and localizes to the endoplasmic reticulum.{1299,1394} The COX component converts arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607) to a hydroperoxyl endoperoxide prostaglandin G2 (PGG2; Item No. 17010) and the peroxidase component reduces the endoperoxide to the corresponding alcohol PGH2 (Item No. 17020), the precursor of PGs, thromboxanes, and prostacyclins.{500,501} COX-1 is the target of many non-steroidal anti-inflammatory drugs (NSAIDs) and is responsible for the undesirable gastrointestinal and renal side effects, such as ulcer formation and reductions in the glomerular filtration rate, respectively.{5282,4411} Cayman’s COX-1 Monoclonal Antibody (Clone CX111) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

• Artikelnummer: CAY160110-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 160110-500
• Green Labware: Nein
• Verpackungseinheit: 1 ea (500 µg)
• Mengeneinheit: STK
• Reaktivität: Sheep (Ovine)
• Klonalität: Monoclonal
• Methode: Western Blotting, Immunohistochemistry
• Isotyp: IgG2b
• Wirt: Mouse