COX-2 Monoclonal FITC Antibody (Clone CX229)

Formulation: 100 μg of FITC-labeled purified monoclonal antibody

Immunogen: Synthetic peptide from the C-terminal region of human COX-2

Clone Designation: CX229

Shelf life (days): 365

Notes: Cyclooxygenase 2 (COX-2) is a bifunctional enzyme that exhibits both COX and peroxidase activities and catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins.{500,501} The COX component converts arachidonic acid to the hydroperoxy endoperoxide prostaglandin G2 (PGG2; Item No. 17010), and the peroxidase component reduces the endoperoxide to the corresponding alcohol PGH2 (Item No. 17020). COX2 expression is induced by a variety of stimuli, including phorbol esters, LPS, and cytokines and is responsible for the biosynthesis of PGs under acute inflammatory conditions.{54420,14766} Thus, COX-2 has been the focus of attention for nonsteroidal anti-inflammatory drug (NSAID) development. Cayman's COX-2 Monoclonal FITC Antibody (Clone CX229) can be used for flow cytometry (FC), immunocytochemistry (ICC), and immunofluorescence (IF) applications. The antibody recognizes a unique C-terminal region of COX-2 that is not present in COX-1, specifically detecting COX-2 in human and ovine samples.

• Artikelnummer: CAY160113-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 160113-100
• Green Labware: Nein
• Verpackungseinheit: 1 ea (100 μg)
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Flow Cytometry, Immunocytochemistry
• Isotyp: IgG1
• Wirt: Mouse