Crotonaldehyde Antibody, Clone 2A8.1: APC

Mouse Anti-Crotonaldehyde Monoclonal IgG1

Target: Crotonaldehyde

Conjugate: APC

Product Type: Monoclonal

Clone Number: 2A8.1

Immunogen: Crotonaldehyde modified Keyhole Limpet Hemocyanin (KLH)

Purification: Protein G Purified

Storage Buffer: PBS pH 7.4, 50% glycerol, 0.09% Sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Specific for Crotonaldehyde modified proteins. Does not cross-react with Acrolein, Hexanoyl Lysine, 4-Hydroxy-2-hexenal, 4-Hydroxy nonenal, Malondialdehyde, or Methylglyoxal modified proteins.

Scientific Background: Lipid peroxidation occurs when oxidizing agents attack carbon-carbon double bonds found in unsaturated lipids. In addition to membrane degradation, oxidation end-products have been found to damage cell viability through their mutagenic and toxic properties. These downstream functional consequences facilitate the development of disease and premature aging. Crotonaldehyde (CRA) is a carcinogenic, conjugated aldehyde produced endogenously via lipid peroxidation. It covalently modifies biomolecules, forming adducts with DNA and nucleophilic amino acid residues of proteins such as lysine (1).

References: 1. Ichihashi, K. et al. (2001) J Biol Chem. 276, 23903-23913.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-534D-APC
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-534D-APC
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Various species
• Klonalität: Monoclonal
• Methode: Western Blotting, ELISA
• Isotyp: IgG1
• Wirt: Mouse