CT3, CAS 2403729-27-9

Formulation: A solid

Formal Name: 1-[2-[5-[5-fluoro-2-(trifluoromethyl)-3-pyridinyl]-1,3-dihydro-2H-isoindol-2-yl]-2-oxoethyl]-1H-1,2,4-triazole-3-carbonitrile

Purity: ≥98%

Formula Markup: C19H12F4N6O

Formula Weight: 416,3

Shelf life (days): 1095

CAS Number: 2403729-27-9

Notes: CT3 is a cyanotriazole antiparasitic.{51503} It is active against T. b. brucei, T. b. gambiense, T. b. rhodesiense, T. cruzi, and L. donovani (EC50s = 180, 31, 57, 78, and 134 nM, respectively). CT3 (4 µM) inhibits nuclear, but not kinetoplastid, DNA replication in the bloodstream form of T. b. brucei. It inhibits T. cruzi topoisomerase II but not human topoisomerase II-α. CT3 (30 mg/kg per day for five days) eradicates T. cruzi in a mouse model of Chagas disease. It also eradicates the T. b. brucei strain STIB975 at stage I and stage II in a mouse model of African trypanosomiasis when administered at a dose of 10 mg/kg for four or seven days, respectively.

• Artikelnummer: CAY39416-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39416-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK