Cucurbitacin D, CAS 3877-86-9

Formulation: A solid

Formal Name: (2β,9β,10α,16α,23E)-2,16,20,25-tetrahydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione

Purity: ≥98%

Formula Markup: C30H44O7

Formula Weight: 516,7

Shelf life (days): 1460

CAS Number: 3877-86-9

Notes: Cucurbitacin D is a triterpenoid that has been found in Cucurbita texana and has diverse biological activities.{69087,69088,69089} It decreases levels of the heat shock protein 90 (Hsp90) client proteins HER2, Raf, and cyclin-dependent kinase 6 (Cdk6) in MCF-7 breast cancer cell lysates in a concentration-dependent manner and inhibits the proliferation of MCF-7 cells (IC50 = 0.598 µM).{69087} Cucurbitacin D (0.1 µM) inhibits cigarette smoke condensate-induced HIV-1 replication in chronically HIV-1-infected U1 macrophages.{69088} In vivo, cucurbitacin D (0.025 mg/kg) decreases cold and mechanical allodynia in a mouse model of neuropathic pain induced by paclitaxel (Item No. 10461).{69089}

• Artikelnummer: CAY36172-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36172-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe