Cyclin D1(DCS-6), 1mg/mL

Description: Recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). About 40% of breast carcinomas are positive for Cyclin D1. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Conjugate: Purified, BSA-free

Concentration: 1 mg/mL

Storage buffer: PBS, no BSA, no azide

Product Origin: Animal - Mus musculus (mouse)

Clone: DCS-6

Entrez Gene ID: 595

Immunogen: Human full length recombinant cyclin D1 protein

Verified AB Applications: Flow (intracellular) (verified)/IHC (FFPE) (verified)/WB (verified)

Z-Antibody Applications: Flow, intracellular (verified)/IHC, FFPE (verified)/WB (verified)

• Artikelnummer: BTMBNUM0007-50
• Hersteller: Biotium
• Hersteller Artikelnummer: BNUM0007-50
• Green Labware: Nein
• Verpackungseinheit: 50 uL
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus), Monkey (Primate)
• Klonalität: Monoclonal
• Methode: Western Blotting, Flow Cytometry, Immunohistochemistry
• Isotyp: IgG2a kappa
• Wirt: Mouse