Product Type: Inhibitor
CAS No.: 4449-51-8
MolecularFormula: C27H41NO2
Molecular Weight: 434,15
Source: Synthetic
Purity: >98%
Solubility: Soluble to 5 mM in ethanol
Appearance: White Solid
PubChem CID: 442972
Scientific Background: Cyclopamine is a hedgehog signaling pathway inhibitor that influences the balance between the active and inactive forms of the Smoothened protein (1). It is being investigated as a treatment agent in basal cell carcinoma, medulloblastoma and rhabdomyosarcoma (1, 2). Cyclopamine is also being investigated as a novel regulator of γ-secretase-mediated cleavage of APP (3).
References: 1. Beachy P.A., et al. (2000) Nature. 406(6799): 1005-1009.2. Yauch R.L., et al. (2009) Science. 326(5952): 572-574. 3. Vorobyeva A.G., et al. (2014) J Biol Chem. 289(48): 33258-33274.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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