DAPT, CAS 208255-80-5

γ-secretase inhibitor

Product Type: Inhibitor

CAS No.: 208255-80-5

MolecularFormula: C23H26F2N2O4

Molecular Weight: 432,46

Source: Synthetic

Purity: >99%

Solubility: Soluble to 100 mM in DMSO

Appearance: White to off-white powder

PubChem CID: 5311272

Scientific Background: Inhibitor of γ-secretase; causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. Does not affect APPα and APPβ levels. Blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation.

References: 1. Dovey H.F., et al. (2001) J. Neurochem. 76(1): 173-81. 2. De Smedt M., et al. (2005) Blood. 106(10): 3498-506.3. Kanungo J., et al. (2008) J. Neurochem. 106(5): 2236-48.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-378-25MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-378-25MG
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK