Product Description: DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.
Applications: Cancer-programmed cell death
Formula: C35H30ClN5O4S2
References: [1]Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.
CAS Number: 501666-85-9
Molecular Weight: 684.23
Compound Purity: 98.0
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: ADC Cytotoxin