Delgocitinib, CAS 1263774-59-9

Formulation: A solid

Formal Name: (3S,4R)-3-methyl-β-oxo-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octane-1-propanenitrile

Purity: ≥98%

Formula Markup: C16H18N6O

Formula Weight: 310,4

Shelf life (days): 1460

CAS Number: 1263774-59-9

Notes: Delgocitinib is an inhibitor of JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2; IC50s = 2.8, 2.6, 13, and 58 nM, respectively).{64909} It is selective for JAK1, JAK2, JAK3, and TYK2 over lymphocyte cell-specific tyrosine kinase (LCK; IC50 = 5,800 nM). Delgocitinib inhibits IL-31-induced increases in STAT3 phosphorylation levels in A549 cells (IC50 = 25 nM). It reduces IL-31-induced scratching in mice in a dose-dependent manner.{64910} Formulations containing delgocitinib have been used in the treatment of atopic dermatitis.

• Artikelnummer: CAY38307-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38307-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe