DHCR7 antibody (HL2764)

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Clone Name: HL2764

Light Chain: Kappa

Application Note: WB: 1:500-1:10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 54

Form: Liquid

Buffer (with preservative): PBS, no Preservative.

Concentration: batch dependent (Please refer to the vial label for the specific concentration.)

Background: This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by cognitive disability, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Aug 2009]

Uniprot ID: Q9UBM7

Antigen Species: Human

Immunogen: Recombinant fragment of human DHCR7.

Purification: Affinity purified by Protein A.

Conjugation: Unconjugated

Full Name: 7-dehydrocholesterol reductase

• Artikelnummer: GTX639629-100
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX639629-100
• Verpackungseinheit: 100 μl
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Western Blotting
• Isotyp: IgG
• Human Gene ID: 1717
• Wirt: Rabbit
• Konjugat: Unconjugated