Dp44mT, CAS 152095-12-0

Formulation: A crystalline solid

Formal Name: 2-(di-2-pyridinylmethylene)-N,N-dimethyl-hydrazinecarbothioamide

Purity: ≥98%

Formula Markup: C14H15N5S

Formula Weight: 285,4

Shelf life (days): 1460

CAS Number: 152095-12-0

Notes: Dp44mT is an iron chelator with antiproliferative effects.{38957} It inhibits in vitro proliferation of SK-N-MC neuroepithelioma, SK-Mel-28 melanoma, and MCF-7 breast cancer cells (IC50s = 30, 60, and 60 nM, respectively) but not of normal MRC-5 fibroblasts (IC50 = >25 µM). Dp44mT increases mobilization of 59Fe from SK-N-MC cells and M109 mouse lung carcinoma cells when used at concentrations of 25 and 1 µM, respectively. It dose-dependently increases apoptosis in M109 cells in vitro. Dp44mT (2.5 µM) increases expression of the metastasis suppressor protein NDRG1 in the DU145 and PC3 human prostate cancer cell lines to a greater degree than normal prostate epithelial cells (PrECs), while also increasing expression of the tumor suppressor protein PTEN in both DU145 cells and normal PrECs.{38958} Dp44mT also enhances cytotoxicity in several multidrug resistant human cancer cell lines following transport to lysosomes by P-glycoprotein.{38959} Dp44mT (0.4 mg/kg) inhibits M109 tumor growth in mice, reducing tumor weight to 47% of control.{38957} It also reduces tumor size and weight in an oral squamous cell carcinoma mouse xenograft model when administered at a dose of 0.5 mg/kg.{38960}

• Artikelnummer: CAY20936-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 20936-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK
• Methode: Reinstoffe