DPY30, His-tag Recombinant

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Encompassing Amino Acids: 2-99 (end)

Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. 

Background: As part of the MLL1/MLL complex, involved in the methylation of histone H3 at Lys-4, particularly trimethylation. Histone H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 Lys-4 methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.

Description: Human dpy-30 homolog, or DPY30, GenBank Accession No. NM_032574, a.a. 2 - 99 (end) with N-terminal His-tag, MW= 12 kDa, expressed in an E. coli expression system.

Format: Aqueous buffer solution

Formulation: 45 mM Tris-HCl pH 8.0, 124 mM NaCl, 2.4 mM KCl, 225 mM Imidazole, 1 mM TCEP, 1 µM ZnCl2, 10% Glycerol

Genbank: NM_032574

Storage Stability: At least 6 months at -80°C.

Tags: N-terminal His-tag

Uniprot: Q9C005

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: 1. Xu, Z., et al., J Cell Biol. 2009 Aug 10 ; 186(3) : 343-53
2. Patel, A., et al., J Biol Chem. 2009 Sep 4 ; 284(36) : 24242-56

• Artikelnummer: BPS71203
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 71203
• Green Labware: Nein
• Verpackungseinheit: 50 µg
• Mengeneinheit: STK