dsDNA Monoclonal Antibody (Clone 2C4)

Formulation: 200 µg of ammonium sulfate-purified monoclonal antibody

Clone Designation: 2C4

Shelf life (days): 1095

Notes: In response to stimuli, neutrophils have the ability to release net-like structures containing nuclear DNA, de-condensed histones, and antimicrobial peptides.{19770} These neutrophil extracellular traps (NETs) have the ability to contact and kill pathogens including fungi, bacteria, and protozoa; they are then rapidly cleared by the immune system.{24590,24587,25672} However, in aged NZBWF1 mice and human lupus patients, the clearance is delayed, allowing formation of antibodies to these NET components. Cayman’s dsDNA Monoclonal Antibody was developed by fusing the spleen of a non-immunized NZBWF1 mouse with a mouse myeloma cell line. It detects dsDNA by ELISA and can be used to stain NETs by immunofluorescence.

• Artikelnummer: CAY15635-200
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 15635-200
• Green Labware: Nein
• Verpackungseinheit: 1 ea (200 µg)
• Mengeneinheit: STK
• Klonalität: Monoclonal
• Methode: Immunofluorescence, ELISA, Flow Cytometry, Immunohistochemistry
• Isotyp: IgM
• Wirt: Mouse