E-4031, CAS 113558-89-7

Herg channel blocker

Product Type: Inhibitor

CAS No.: 113558-89-7

MolecularFormula: C₂₁H₂₇N₃O₃S · 2HCl · 2H₂O

Molecular Weight: 510.5

Source: Synthetic

Purity: >98% (TLC: CH2Cl2/CH3OH; 9:1 with 1% NH4OH; Silica gel 60; Rf=0.39); NMR conforms

Solubility: Soluble in water (100 mg/ml) and warm DMSO (25 mg/ml)

Appearance: White solid

PubChem CID: 5312116

Scientific Background: E-4031 acts on a specific class of voltage gated potassium channels, the hERG channels. It does this by binding to the open channels, although its structural target is unclear (1-4). It is also an anti-arrhythmic drug (5).

References: 1. Gerlach A.C., Stoehr S.J., Castle N.A. (2010) Mol Pharmacol. 77(1): 56-68.2. Perrin M.J., et al. (2008) Prog Biophys Mol Biol. 98: 137-148.3. Sanguinetti M.C., Jurkiewicz N.K. (1990) J Gen Physiol. 96: 195-215.4. Spector P.S., Curran M.E., Keating M.T., and Sanguinetti M.C. (1996) Circ Res. 78: 499-503.5. Miyake K., et al. (1990) J Med Chem. 33: 903.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-317-50MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-317-50MG
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK