E70K (trifluoroacetate salt)

Formulation: A solid

Purity: ≥98%

Formula Markup: C108H178N34O28 • XCF3COOH

Formula Weight: 2400,8

Shelf life (days): 1460

Notes: E70K is an inhibitor of the chemokine-glycosaminoglycan interaction between chemokine (C-X-C) ligand 8 (CXCL8) and glycosaminoglycans (GAGs) on the exterior of cell membranes.{65794} It corresponds to an amino acid sequence from the CXCL8 C-terminal GAG-binding region and contains a glutamate-to-lysine substitution at position 70. E70K (50 nM) inhibits primary human neutrophil binding to human umbilical vein endothelial cells (HUVECs). It decreases CXCL8-induced transendothelial migration of primary human neutrophils through HMEC-1 human microvascular endothelial cell layers when used at concentrations ranging from 1 to 1,000 nM.

• Artikelnummer: CAY36956-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36956-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK