Ebola Virus VP24 (subtype Zaire, strain H. sapiens-wt/GIN/2014/Kissidougou-C15) (recombinant)

Formulation: Lyophilized from sterile 50 mM Tris, with 500 mM sodium chloride

Purity: ≥95% estimated by SDS-PAGE

Formula Weight: 0

Shelf life (days): 365

Notes: Ebola virus (EBOV) is an enveloped and negative-stranded RNA virus, a member of the Ebolavirus genus, and the causative agent of Ebola virus disease (EVD), a condition characterized by a hemorrhagic fever and a high mortality rate, that is endemic to western and equatorial Africa.{69796} The single-stranded RNA genome of EBOV encodes seven proteins: nucleoprotein (NP), virion protein 40 (VP40), VP35, VP30, VP24, glycoprotein (GP), and an RNA-dependent RNA polymerase (L).{69796,69797} EBOV VP24 is a monomeric structural protein that is composed of N- and C-terminal domains that form a pyramidal structure.{51796} It functions with VP35 and NP in nucleocapsid formation, and both N- and C-terminal domains of VP40 are required for proper nucleocapsid structure.{51798,69796} EBOV VP24 disrupts the innate immune viral response by inhibiting expression of the gene encoding IFN-λ1 and prevents phosphorylated STAT1 nuclear translocation and transcriptional activity in mammalian cells expressing VP40.{69796,51797,51796} Cayman's Ebola Virus VP24 (subtype Zaire, strain H. sapiens-wt/GIN/2014/Kissidougou-C15) (recombinant) protein consists of 233 amino acids and has a calculated molecular weight of 28.5 kDa.

• Artikelnummer: CAY41067-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 41067-100
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK